When Harry Levine, an aging, unsuccessful Greenwich Village writer is fired from his job as restaurant doorman, he calls on friend and mentor Jake, ostensibly to collect a long-standing debt. Harry solicits his opinion on his latest manuscript, a work of semi-fiction based on their longtime friendship. Although he initially denies having read it, Jake later attacks it on aesthetic grounds, and deep-seated feelings of betrayal and jealousy surface and lead to a traumatic confrontation.

Quadripeligic ex-cop Lincoln Rhyme was looking forward to his assisted suicide when he got the news: some sicko was abducting people in a taxi and leaving them to die in particularly sadistic ways. With time counting down between each abduction and possible death, Rhyme recruits rather-unwilling Amelia Donaghy, haunted by her cop father's suicide and thinking she's next, into working the crime scenes to track down the killer.